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Other In line with the crucial roles of methylation in reproductive health, immunity, and mental health, studies have observed a potential link between MTRR rs1801394 and: Colorectal and other types of cancer [R, R] Male fertility issues (mostly in Asians) [R, R] ADHD in children [R] How It Works The primary SNP, rs1801394, changes one amino acid in the MTRR structure, diminishing its ability to bind and activate MTR

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