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2020;6:eabc5629
The lack of B12 halts the methylation cycle, which leads to a buildup of toxic homocysteine

This does not invalidate the findings, but it means the evidence base is not yet at the level of FDA-approved pharmaceuticals
Quantitative Real-Time Polymerase Chain Reaction (qRT-PCR) Two concentrations (1.0 and 2.5 mM) of Cys (CL and CH groups, respectively), GSH (GL and GH groups, respectively), and MIX (ML and MH groups, respectively) were tested in HepG2 cells
This has been a significant growth driver over the past few years, and it continues to point to a bright future for the platform

(PubMed) Ascherio A, Hennekens C, Willett WC, et al