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However, traditional therapies exhibit nonspecific targeting, high rates of severe adverse reactions, low bioavailability, and drug resistance development, all of which limit therapeutic efficacy [12,13,14]

Lactobacillus acidophilus alleviates type 2 diabetes by regulating hepatic glucose, lipid metabolism and gut microbiota in mice

It achieves this by downregulating apoptotic pathway markers such as NO, cytochrome-c, caspase-9, and caspase-3 in the liver [123]

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In a larger clinical study involving 479 patients with chronic primary glomerulonephritis, the combination of AC, isolated from Rehmannia glutinosa , and irbesartan led to a 36.42% reduction in proteinuria significantly greater than the 27.97% reduction observed in the control group receiving irbesartan alone (Qiu et al

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