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The mechanism is scientifically sound and consistently supported by animal data, but human efficacy and safety have not been established through clinical trials

In contrast, pathological stimulation involved cyclic stretch at 5% or 20% strain at 1 Hz frequency for 20 h in normoxia (21% O 2 ) and in hypoxia (1% O 2 ) combined with 20% cyclic stretch and exposure to NPs

Overall, the development of histone modifications to control ferroptosis is a promising approach

doi: 10.1097/MCO.0000000000000009 138

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