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May-Jun 2015;131(3):34-40, 42-34
A recent study found that COL11A1 activated Src-Akt-AMPK signal transduction by binding to 11 integrin and discoidin domain receptor 2 to up-regulate FAO, making ovarian cancer (OC) cells resistant to cisplatin [64]
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(PubMed) Vacek TP, Kalani A, Voor MJ, Tyagi SC, Tyagi N
Enzymes such as glutaminase (GLS) are frequently upregulated, indicating potential therapeutic targets [27, 28]
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