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Melatonin reduces the formation of destructive toxic hydroxyl radicals by chelating transition metals taking place in Fenton/Haber-Weiss reactions [64]

Biliverdin reductase of guinea pig liver

The underlying pathogenic mechanisms are not fully understood but experimental evidence suggests that osteoblasts (mediators of bone construction) are deficient and their counterparts the osteoclasts have increased survival leading to increased degradation of bony tissue 69

HSP90 inhibitors Heat shock protein 90 (HSP90) is a chaperone involved in cellular homeostasis in different physio-pathological conditions, such as cancer

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