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POMC neurons expressing leptin receptors coordinate metabolic responses to fasting via suppression of leptin levels

The peptide's direct interaction with DNA allows it to regulate expression of genes involved in cellular stress response, protein quality control, and metabolic adaptationall critical factors in healthy aging

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While BAT and subcutaneous adipose tissues are the sites for thermogenesis, the sympathetic nervous system (SNS) involving many brain regions is the driver of thermogenic activation 34

In that study, the authors used young adult (8-10 weeks old) male C57BL/6 mice and performed a dosage screen (from 0.1% to 0.6%) by examining the demyelination in the corpus callosum of cerebral white matter, a brain region where the extent of demyelination can be scored more easily and consistently than the previously described superior cerebellar peduncles with LFB-PAS staining (Skripuletz et al., 2011)