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This evidence is supported by a clinical investigation from Carragee et al

Normal color variation between batches is one thing

The OINDP classification is important because it signals that standard pharmaceutical testing protocols are insufficient nasal sprays require a specialized suite of device performance tests (spray pattern, plume geometry, droplet size distribution, dose uniformity) that are specific to this dosage form and that are detailed in dedicated FDA guidance documents

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Keep in mind that most preclinical research has used injectable delivery, so the oral bioavailability question is relevant context for your evaluation