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They found that the inhibitor CMLD013075 possesses potent fungus-selective Hsp90 inhibitory activity, which can block the changes in the signaling network caused by the stress response, thereby preventing the development of drug resistance of Candida albicans and eliminating drug resistance after development [50, 128, 129]

Devine 1 1 CIBMTR (Center for International Blood and Marrow Transplant Research), NMDP, Minneapolis, United States of America (the), 2 Fred Hutchinson Cancer Center, Seattle, United States of America (the), 3 City of Hope, Duarte, United States of America (the), 4 Oregon Health and Science University, Portland, United States of America (the), 5 Dana Farber Cancer Center, Boston, United States of America (the), 6 University of Virginia, Charlottsville, United States of America (the), 7 University of Pennsylvania, Philadelphia, United States of America (the), 8 MD Anderson, Houston, United States of America (the), 9 University of Miami, Miami, United States of America (the), 10 Karmanos Cancer Center, Detroit, United States of America (the), 11 CIBMTR (Center for International Blood and Marrow Transplant Research), Medical College of Wisconsin, Milwaukee, United States of America (the), 12 Memorial Sloan Kettering Cancer Center, New York, United States of America (the), 13 University of Minnesota, Minneapolis, United States of America (the) Background : The ACCESS trial (NCT04904588) showed favorable combined one-year overall survival (81%) after mismatched unrelated donor (MMUD) hematopoietic cell transplantation (HCT) in 145 adult patients using post-transplantation cyclophosphamide (PTCy, 50 mg/kg Days 3&4) (PMID 40523209)

Copper induces cell death by targeting lipoylated TCA cycle proteins

The Mini-balance evaluation systems test (Mini-BESTest) demonstrates higher accuracy in identifying older adult participants with history of falls than do the BESTest, berg balance scale, or timed up and go test

Chronic phosphocreatine depletion by the creatine analogue beta-guanidinopropionate is associated with increased mortality and loss of ATP in rats after myocardial infarction