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The fact that mutant ATXN3 aggregates are also found in axons and that components that ensure protein homeostasis are in close proximity led to the hypothesis that the aggregation process occurring within axons may affect mechanisms of axonal transport of mRNA, proteins, and organelles and thereby contribute to a wider neuronal dysfunction in SCA3 [30]

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Brain-gut Axis and Pentadecapeptide BPC 157. Curr Pharm Des 24(18):19721989