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A landmark phase III trial (URCC CCOP study) tested modafinil in 631 patients receiving chemotherapy (including many breast cancer patients), and found that modafinil significantly reduced fatigue only in the subset of patients who had severe baseline fatigue those with moderate fatigue did not derive a clear benefit [58]

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Tripathy D, Mohanty P, Dhindsa S, Syed T, Ghanim H, Aljada A, et al

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Several mechanisms control the expression and activity of MCAD, including transcriptional regulation, post-translational modifications, and substrate availability

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Ylmaz et al

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It has also been indicated to be helpful in the treatment of neurodegenerative diseases, such as Alzheimer's

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