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The enzyme can no longer be saturated with GSH in the R73 and R74 mutants leading to the paradoxical situation that mutation decreases activity at low GSH but increases activity at very high GSH concentrations

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Subsequent studies have found that GLP-1 can reduce the risk of PD in type 2 diabetes [166]

The glutathione peroxidase reaction: molecular basis of the antioxidant function of selenium in mammals

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