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Tesofensine (NS2330) is a triple monoamine reuptake inhibitor that blocks the reuptake of norepinephrine, dopamine, and serotonin

Methylation issues are very common (up to 40% of patients) and many patients unknowingly supplement with cyanocobalamin which may increase serum levels but will not improve symptoms 5

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For instance, treatment with the NRK-salvage precursor NR in mice, C
