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ROS are metabolic by-products acting as signalling molecules (regulate cell growth and death) and mediators of inflammation

We, therefore, predict that GSH will be required to prevent FA toxicity in Fanconi Anaemia by limiting endogenous free FA level

This 83-amino-acid polypeptide features an arginine substitution for glutamic acid at position 3, plus an additional 13-amino-acid N-terminal extension (MFPAMPLLSLFVN)

The mitochondrial impairment in FM is evident from reduced bioenergetic health index (BHI) and increased mitochondrial miRNAs (mitomiR-145-5p) in peripheral blood mononuclear cells (PBMCs), which regulate oxidative stress responses (4)

C.PasolliH

Additionally, the excess iron ions metabolized by microglia are expelled through the transferrin receptor system, leading to a significant accumulation of iron in neurons (55)