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Iron is then transported in the plasma as a complex with transferrin (Tf), which is detected by transferrin receptor 1 (TfR1) or 2 (TfR2) and endocytosed as the Fe-Tf complex [12] (Figure 2)

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10.1007/s00018-012-1010-9 [DOI] [PMC free article] [PubMed] [Google Scholar] Altenhfer S, Radermacher KA, Kleikers PW, Wingler K, Schmidt HH (2015) Evolution of NADPH oxidase inhibitors: selectivity and mechanisms for target engagement