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doi:10.1186/s41043-021-00263-w 32

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Simultaneous micro-determination of nicotinamide and its major metabolites, N1-methyl-2-pyridone-5-carboxamide and N1-methyl-4-pyridone-3-carboxamide, by high-performance liquid chromatography

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This lipotoxicity and oxidative stress vicious cycle creates a metabolic trap, which is particularly evident in glomerular mesangial cells and proximal tubular cells, thereby driving extracellular matrix deposition and the development of renal fibrosis

He K, Liu K, Daviglus ML, Morris SJ, Loria CM, Van Horn L, Jacobs DR, Savage PJ