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or it may be secondary, in which the individual develops the condition because of other metabolic disorders The signs and symptoms of Carnitine Deficiency Syndrome may include irritability, fatigue, abnormal liver enlargement, and failure to thrive in children

While the origins of the observed differences between mice and humans with respect to the l-carnitineBBTMATMAO pathway are not clear, the fact that the second reaction in the conversion of l-carnitine into TMA (i.e., BBTMA) showed marked induction with dietary exposure in subjects likely plays a major role in the observed differences

Specifically, mechanistic findings reveal that TLR5 promotes assembly of the MyD88 complex, which amplifies the TLR4/MyD88-dependent signaling cascade [44] (Figure 2)

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Andrology 1 , 120128 (2013)