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doi: 10.1016/j.cvsm.2007.10.001

[DOI] [PMC free article] [PubMed] [Google Scholar] Baqer M

349 If the ulcers fail to show a 50% reduction after 4 weeks of appropriate management via conventional methods, several advanced therapies, including negative-pressure therapy, growth factor therapy, bioengineered tissue, acellular matrix tissue, stem cell therapy, hyperbaric oxygen therapy, and, most recently, topical oxygen therapy, can be considered
A B12 deficiency causes: distinctive dyserythropoietic abnormalities in the bone marrow megaloblastic erythropoiesis which is associated with abnormally large red cells in the peripheral cells, for example macrocytosis
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Additional information Peer review information Nature Metabolism thanks Amir Zarrinpar and the other, anonymous, reviewers for their contribution to the peer review of this work
