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Bacteria utilize regulatory systems such as Fur and PerR to maintain metal homeostasis under oxidative stress

The matched increase in glutamate and decrease in aspartate may suggest an activity-induced alteration in relative distribution of these two amino acids in their association with the malateaspartate shuttle (MAS) (Mangia et al., 2012)

This suggests the PHB-ANXA2 system has multiple roles in fat biology, and FTPP may be affecting more pathways than just the obvious vascular destruction

Bergan-Roller HE, Sheridan MA

Network biology implemented computational models to interpret gene regulatory networks (GRNs) (289), protein-protein interaction (PPI) networks (290) and signaling cascades (291), characterizing the key modules, hubs, and bottlenecks linked with cancer phenotypes