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With the growth in elderly population and inflation in life expectancy, cognitive and memory impairments linked to age-related neurodegenerative disorders that have become a considerable public health issue [26]

Plasmids and constructs Single guide RNAs (sgRNAs, Supplementary Table 2) were designed using the VBC score sgRNA prediction tool 82 and cloned into a lentiviral vector enabling expression of the sgRNA and IRFP670 (pLenti-hU6-sgRNA-PGK-IRFP670)

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So these are studies that are genome-wide associated studies

Nrf2 Regulates Basal Glutathione Production in Astrocytes. International Journal of Molecular Sciences 26: 687