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Doitsh G, Greene WC

Immunogenicity of mAbs in non-human primates during nonclinical safety assessment

doi: 10.3389/fphar.2024.1329743 Received 02 November 2023 Accepted 11 April 2024 Published 09 May 2024 Volume 15 - 2024 Edited by Adolfo Andrade-Cetto, National Autonomous University of Mexico, Mexico Reviewed by Chenghai Liu, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, China Fan Yang, Jiangxi Agricultural University, China Rolf Teschke, Hospital Hanau, Germany Updates Copyright 2024 Lao, Wang, Zhu, Yuan, Ma and Wang

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314 LPS from gram-negative bacteria amplifies this process via TLR4 signaling, recruiting neutrophils and releasing IL-1, exacerbating renal inflammation

NNMTi was shown to have high permeability to the membrane in a bidirectional permeation assay in Caco-2 cells