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Prior to the trial, the older cohort exhibited severe intracellular glutathione deficiency, massive oxidative stress, and impaired mitochondrial function compared to young, healthy controls

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Nevertheless, prescribers are advised to limit the daily dose to a maximum of 250 mg in adults and 3 mg/kg (or 200 mg) in children and adolescents ( seeDOSAGE AND ADMINISTRATION)
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Role of the liver in interorgan homeostasis of glutathione and cyst(e)ine

A developmental redox dysregulation leads to spatio-temporal deficit of parvalbumin neuron circuitry in a schizophrenia mouse model