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One study investigating the role of nutrition in DNA replication, DNA damage prevention, and DNA repair confirmed that folate and vitamin B12 are required for nucleotide synthesis and DNA replication, as well as the maintenance of DNA methylation and chromosome stability

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464 In addition, colchicine appears to reduce inflammatory signaling in blood vessels by suppressing oxidized LDL-cholesterol-induced activation of the NLRP3 inflammasome protein complex

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Inflammation The immune response is initiated by injuryinduced signals including damageassociated molecular patterns (DAMPs) released by necrotic cells and damaged tissue, and pathogenassociated molecular patterns (PAMPs) from bacterial components such as lipopolysaccharide [2]

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