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Although initially characterized as a quality control mechanism, NMD is currently recognized as a broader regulatory pathway that contributes to transcriptome homeostasis [11]

6-Phosphogluconolactonase then hydrolyzes the lactone to 6-phosphogluconate via a proton-relay mechanism involving conserved histidine and aspartate residues

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Glutathione traps free radicals and toxins and removes them from the body

Further supporting this notion of the bidirectional relationship between age and sleep-wake disruption, studies have noted that behavioral or genetic manipulation of circadian rhythms also causes aging-like phenotypes (Hood and Amir, 2017)