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In people with adequate B12 levels, additional supplementation does not enhance energy beyond normal physiological function

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in Nature Medicine found that NNMT inhibition in white adipose tissue increased energy expenditure and reduced fat mass in animal models without altering food intake or physical activity (Kraus et al., Nature Medicine )

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NAD+ Restoration: By blocking NNMT, 5-Amino-1MQ prevents the degradation of Nicotinamide, allowing it to be recycled back into NAD+ via the salvage pathway