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Description
High-dose supplementation, particularly hydroxocobalamin injections, has been associated with acne-like eruptions and rosacea flare-ups in susceptible individuals

Most of these are in southeast Africa or Central America

Annu Rev Pharmacol Toxicol

Transcription and gene-expression studies: Measuring changes in ERR-regulated gene markers using reporter assays, qPCR panels, RNA sequencing, or protein-expression workflows

Entirely different mechanisms

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