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10.1016/j.jddst.2019.101356 6 As-SanieS.MackenzieS

In some cases, Ses anti-inflammatory and antioxidant effects may help reverse the enlargement of the thyroid, especially when Se deficiency is a significant factor in the development of goiter [63]

doi: 10.1089/ars.2010.3393 50 MarinhoHSCyrneLCadenasEAntunesF

In hepatocellular carcinoma (HCC), further modification of such nanoparticles with sorafenib combined with radiotherapy enables a tri-modal attacksimultaneously inhibiting tumor proliferation, disrupting redox homeostasis, and activating ferroptosis pathwaysthereby overcoming radiotherapy resistance and improving therapeutic outcomes (203)

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CTLA-4 Cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) represents another pivotal checkpoint molecule that negatively regulates T cell activation