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Gastroenterology 113 (2), 430433

Common regimens include 50 mg/kg intraperitoneally twice daily for 1228 days in C57BL/6J or ob/ob mice, with indirect calorimetry and body-composition endpoints

All data is from preclinical laboratory research and does not constitute human safety data or side effect information in any clinical sense

Two practical consequences fall out of this mechanism, and both explain the shape of the protocol below

This provides an important tool for research into aging-related neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease, and offers experimental evidence for intervention strategies in neuronal aging

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