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Concurrently, NAD + depletion, exacerbated by poly(ADP-ribose) polymerase-1 (PARP-1) hyperactivation, cripples sirtuin activity, impairing mitochondrial biogenesis via peroxisome proliferator-activated receptor gamma coactivator 1 alpha (PGC-1) dysregulation and reducing antioxidant defense through Forkhead box O (FOXO) signaling

Liver samples were deproteinized with a six-fold volume of cold acetonitrile (1:1 ratio), subjected to intermittent vortexing on ice for 30 min at 4 C, then centrifuged at 18,000 g

[DOI] [PubMed] [Google Scholar] 218.Wiens D, DeSoto MC

Li X, Kockaya G, Research E, Wang H, Ni Y

the prefix sym means same, so sympatric means same homeland in contrast to allopatric meaning other homeland. A number of mechanisms for sympatric speciation have been proposed and studied