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for example, nutritional interventions in Menieres disease aim to boost intrinsic cellular defenses in vulnerable neurons like ganglion cells (Scuto et al., 2020), a concept that could be extended to pharmacologically protecting auditory neurons via targeted epigenetic modulation

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Subjects received an 80 mg/kg dose of one APAP formulation, followed by a washout period and subsequent administration of the second 80 mg/kg formulation of APAP

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demonstrated that single nucleotide polymorphisms (SNPs) of the AS3MT gene ought to be considered when determining the therapeutic dose of ATO, and that the urinary primary methylation index (PMI) can be used as a monitoring indicator of ATO-related chronic adverse reactions (AEs) (Zheng et al., 2021)