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iii Thusius NJ, et al
By preventing PD-1 on T cells from engaging PD-L1 on antigen-presenting cells or hepatocytes, these inhibitors release the inhibitory signal and revive cytotoxicity
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Phosphodiesterase inhibitors (PDE-Is) Phosphodiesterases (PDEs) regulate the concentration of cyclic adenosine monophosphate (cAMP), a key second messenger in both eukaryotic and prokaryotic systems [106]
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