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Apremilast, an oral phosphodiesterase 4 inhibitor, in patients with difficult-to-treat nail and scalp psoriasis: results of 2 phase III randomized, controlled trials (ESTEEM 1 and ESTEEM 2) J Am Acad Dermatol

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[DOI] [PubMed] [Google Scholar] 69.Salven P, Lymboussaki A, Heikkil P, Jskela-Saari H, Enholm B, Aase K, et al

Daily supplementation with fresh Angelica keiskei juice alleviates high-fat diet-induced obesity in mice by modulating gut microbiota composition (in Eng)

Healthcare providers might prescribe such a high dose to correct a deficiency, but it is too much to take without medical supervision