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How fine particulate matter (PM2.5) reaches the brain via the bloodstream and olfactory nerve to drive microglial activation, blood-brain-barrier disruption, oxidative stress and tau pathology

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233 Sodium-glucose cotransporter-2 (SGLT2) inhibitors are commonly used for type 2 diabetes treatment, and in recent years, SGLT2 inhibitors canagliflozin has been shown to suppress IL-6 and IL-1 levels and MPO enzyme activity in the colon of UC rats by downregulating the expression of NF-B p65, thereby reducing colonic inflammatory cell infiltration and oxidative stress

A combination of ALA (50 M) and palmitoyl-ethanolamide (5 M) could reduce OxS (overproduction of ROS and NO) and modulate the major inflammatory cytokines (IL-, IL-6,TNF, and IL-10) involved in COVID-19 infection 534

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