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This compromised mitochondrial function is driven by the combination of a shortfall in glutathione precursor amino acids (cysteine and glycine) and the accumulation of homocysteine (a toxic transsulfuration/glutathione biosynthesis pathway intermediate) [93]

Alpha-lipoic acid (-AL) is considered the universal antioxidant because it is an amphipathic molecule that may act in both aqueous and hydrophobic environments

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Toxicol Vitro 22, 10081017