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Genetic impairments in folate enzymes increase dependence on dietary choline for phosphatidylcholine production at the expense of betaine synthesis

The B-isoform of LDH is mainly expressed in oxidative muscle, and overexpression of Ldhb increases oxidative metabolism [73] in line with the oxidative phenotype we observe

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Wrobel JK, Wolff G, Xiao R, Power RF, Toborek M

In this article, the cellular and systemic roles of cysteine in the metabolic remodelling that occurs in cancer cells will be outlined

It regulates mutant huntingtin protein aggregation and enhances protein quality control systems