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Methods performed were adapted from Webb et al

[DOI] [PubMed] [Google Scholar] Laron Z, Klinger B

This study was supported by the Science and Technology Innovation Program of Hunan Province (Grant number 2023RC3167) and the National Natural Science Foundation of China (Grant number 82300062)

The PCCB gene is located on chromosome 3q22.3 and is composed of 17 exons that generate two alternatively spliced mRNAs encoding proteins of 539 amino acids (isoform 1) and 559 amino acids (isoform 2)

2004), activate Nrf2 to inhibit the expression of BACE1 and BACE1-AS through the modification of the cysteine residue of Keap1 to prevent the production of A, a key pathogenic process in the early stages of AD (Dinkova-Kostova et al

Endoplasmic reticulum stress-a key guardian in cancer