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According to Good Life Family Medicine, semaglutide is the first FDA-approved drug since 2014 for chronic weight management in overweight or obese adults

Do not use a vial when sterility is questionable or when its appearance differs from the product instructions, including unexpected cloudiness, particles, precipitation, or color change

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Pharmacogenetics 3(6):302311 Gil H et al (2014) Diagnostic and therapeutic approach for acute paraquat intoxication

Zheng, C., Lu, T

This is another reason why dangerous, highly-localized injections should be avoided