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Colchicine, another inhibitor of the NLRP3 inflammasome, has been tested in clinical trials and shown to improve endothelial function in patients with leukocyte activation, although it had no effect on endothelial function in the overall patient population [172]

Additionally, it markedly attenuated bone destruction and inhibited the production of tartrate-resistant acid phosphatase (TRAP)-positive osteoclasts [35]

8 Strategies to improve the therapeutic effect of MSCs for IVDD and their challenges in clinical application The microenvironment plays a decisive role in MSC-mediated intervertebral disc regeneration

Early lesions have a central zone of ulceration covered by a fibrinous membrane

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meningitidis is a paradigmatic microorganism that exploits the high plasticity of its genome to continuously adapt to its human host by genome microevolution