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272 The increase in FFAs contributes to cellular lipotoxicity

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Current treatment options include approved drugs such as serotonin-norepinephrine reuptake inhibitors, e.g., duloxetine, gabapentinoids such as pregabalin and gabapentin, topical treatment with capsaicin, and several off-label use drugs such as other antidepressants (e.g., tricyclic antidepressants), antiepileptic drugs, and weak and strong opioids

SAHA shows preferential cytotoxicity in mutant p53 cancer cells by destabilizing mutant p53 through inhibition of the HDAC6-Hsp90 chaperone axis

Activation of sirtuin 1 reduces the intracellular replication of drug-susceptible and drug-resistant Mtb strains in macrophages via the induction of phagosomelysosome fusion and autophagy (149) ( Table 2 )