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Moreover, microbial production of hydrogen sulfide by sulfur-reducing bacteria has been linked to enhanced host GSH production, suggesting that microbial antioxidative agents can regulate the host GPX4/GSH system, thereby further contributing to the protective effects [37, 38]

Activating transcription factor 4 (ATF4), a critical mediator of metabolic and oxidative homeostasis and cell survival (Chen et al., 2017a), inhibits GPX4 by activating heat shock 70 kDa protein 5 to bind to GPX4, thereby promoting ferroptosis (Zhu et al., 2017)

Buchy P, Ascioglu S, Buisson Y, Datta S, Nissen M, Tambyah PA, et al

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