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However, other methods (such as injection) can be considered more effective due to direct delivery

Leukocytes, which are white blood cells, further intensify the ROS production, particularly when releasing inflammatory substances [18]

In K15-Igf1r conditional knockout mice, loss of IGF-1R in follicular stem cells resulted in a decreased number of dermal papilla cells, abnormal follicular morphology, and reduced expression of BMP-4, a key regulator of folliculogenesis [58]

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In endometriosis, upregulation of COX-2 by estrogen, hypoxia, proinflammatory cytokines, environmental pollutants, metabolites and metabolic enzymes, and platelets increases COX-2-derived prostaglandin E2 (PGE2) which can act in a feedback loop for enhanced inflammation (Lai et al., 2019)