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Our bodies naturally decrease in NAD+, with up to 65% decline between ages 30-70

doi: 10.1016/j.bbadis.2005.02.002 75

93,94 In humans, vitamin C has been shown in multiple randomized, double-blind, placebo-controlled trials to help with both depression and anxiety in patients of various ages as well as with opioid addiction

(66) Monocytosis or heterophilia is a common response to acute and chronic inflammatory insults in animals and birds (67) because monocytes, macrophages, and dendritic cells, part of the hematopoietic system, play roles in protection and homeostasis maintenance

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Differential redox regulation of ORAI ion channels: a mechanism to tune cellular calcium signaling