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Additional domains, such as Neh4 and Neh5, recruit the coactivators CREB-binding protein (CBP) and repressor-associated coactivator (RAC) for transcription, whereas the Neh6 and Neh7 domains modulate Nrf2 degradation and repression respectively [18]
Nature 586 , 509515 (2020)
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In vitro, Spirulina-derived C-PC (3 M, 24 h) suppresses VEGFR2 transcription by 1.17-fold in triple-negative breast cancer cells [77] and may additionally interfere with VEGFR1-mediated signaling, as supported by molecular docking analyses [95]
Maintaining results requires continued attention to nutrition, exercise, and possibly periodic peptide cycles
