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doi: 10.1016/j.intimp.2023.111483 192 ZhengYCaiJJYangXShaoZQLiuJQYangXHet al

NAC, ascorbic acid and methylene blue are used as antidotes in the clinical practice

OskarssonMEPaulssonJFSchultzSWIngelssonMWestermarkPWestermarkGT.In vivo seeding and cross-seeding of localized amyloidosis: a molecular link between type 2 diabetes and Alzheimer disease

Glutathione levels are also found to be decreased in central nervous system disorders (such as Alzheimer disease and Parkinson disease), autism, cardiovascular system disorders (atherosclerosis), peripheral vascular disorders, diabetes and its complications, liver disease, acquired immunodeficiency syndrome/human immunodeficiency virus, and chronic obstructive pulmonary diseases

Thus, in the context of a cardiotoxin known to produce superoxide, excess GPx1 mitigated ROS-mediated cardiac damage

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