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These data show that astrocyte-mediated control of extracellular glutamate occurs through an S1P dose-dependent mechanism and is likely mediated through S1P 2

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28,29,30 The complexity and nuances of the basal ganglia circuitry and the widespread innervation of a single nigrostriatal axon, let alone all nigrostriatal inputs, warrant thoughtful consideration regarding techniques for adequate circuit reconstruction

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