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Bio-Manifestation of LEAP-2 Relative to Energy Balance and its Implication to Metabolic Disorders As endogenous ligands of GHS-R1a, LEAP-2 and ghrelin work coordinately to fine-tune GHS-R1a activity according to changes in energy metabolic states

127 In skeletal muscle, TFEB supports mitochondrial homeostasis by activating mitophagy-related genes such as PINK1, PRKN , and BNIP3 , which are essential under metabolic or exercise-induced stress

114 In response to various stimuli, macrophages can differentiate into two unique subsets, referred to as M1 (proinflammatory) or M2 (anti-inflammatory) macrophages

In adults, their activities are more restricted, predominantly in tissue regeneration and damage repair [41,42,43,44]

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The milk intervention group had a 4.6% increase in overall brain GSH concentrations and a 7.4% increase in the parietal region