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Treatment of DOHH2 cells with IACS-16898 reduced global H3K27 acetylation after 24 h (Supplementary Fig

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Mechanism of action Glutathione works through several interconnected roles: Direct antioxidant defence serves as the substrate for glutathione peroxidases (GPx), neutralising hydrogen peroxide and lipid hydroperoxides before they damage membranes and DNA

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In contrast, A1 astrocytes under sustained pro-inflammatory stimuli exhibit fragmented mitochondria due to excessive Drp1-mediated fission and ROS accumulation [133]

[DOI] [PubMed] [Google Scholar] 419.Corriero, A