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Several clinically relevant drug candidates, including TMZ, nitrosoureas, platinum agents, integrin inhibitors, EGFR inhibitors, VEGFR inhibitors, HDAC inhibitors, topoisomerase inhibitors, and doxorubicin, have been loaded into nanocarriers and tested in orthotopic animal models of GBM [164,216]

Ongoing progress in data harmonization, analytical methods, and computational modeling is enhancing knowledge of ADHDs biological complexity and supporting precision medicine strategies that enable patient-specific assessment, targeted interventions, and optimized health outcomes

Many anticonvulsant drugs act by increasing GABA in the synapse.[ref] Genetic variants that decrease the function of the GABA-A receptors essentially decreasing GABA inhibition are linked to an increased risk of epileptic seizures.[ref] Insomnia: Brain GABA levels were studied in people with primary insomnia who were not on medication

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play a key role in cancer chemoprevention by restoring p53 activity [266]

10.1038/nn.2862 21 BenwellM