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The implications of NNMT inhibition extend far beyond simple cofactor availability, influencing fundamental cellular processes including mitochondrial biogenesis, oxidative stress management, and epigenetic regulation
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Tesofensine is a dopamine, serotonin, and noradrenaline (triple) reuptake inhibitor originally developed by NeuroSearch for the treatment of Alzheimer's disease and Parkinson's disease.
Sandi and colleagues describe how mitochondrial functions shape baseline circuit states, support circuit engagement and thereby contribute to cognition and behaviour.
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