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The primary preclinical evidence comes from mouse studies showing reduced body weight and adipose mass in diet-induced obese mice (2018), improved grip strength in aged mice (2024), and beneficial microbiome changes when combined with caloric restriction (2022)

The hypothesized scheme was developed on the basis of the assumption that the 718C variant of the GPX4 gene is responsible for an increased activity or level of this enzyme in the brain

The term curcuminoids encompasses three active compounds: curcumin, demethoxycurcumin, and bisdemethoxycurcumin

doi: 10.1007/s10753-025-02291-8 162 ZhengZZhangSLiuXWangXXueCWuXet al

Our work also revealed striking patterns among the classes of S

Table 3 Summary of positive regulators of pituitary GH: Peripheral factors/other factors
